Summaries by Inventor Shaikh, Nurmohammad

Monoclonal Antibodies to Enterococcus Faecalis Secreted Proteins
Shaikh, Nurmohammad ; Tarr, Phillip
T-011162

— Target: SalB (mAb 6H3) Notes: Reduces inflammatory response.We have identified and characterized monoclonal antibodies that recognize secreted proteins of Enterococcus faecalis, and that neutralize the abilities of whole, viable, E. faecilis to stimulate a pro-inflammatory cytokine in cultured epithelial cells. The monoclonal antibodies are directed against …

IgG Monoclonal Antibodies to Enterococcus Faecalis Gelatinase
Shaikh, Nurmohammad ; Tarr, Phillip
T-011748

— Primary Inventor: Phillip I. Tarr, MD Target: GelE(mAb 8A3)Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn’s disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…